01/03/2010
ReGen Therapeutics Plc (‘ReGen’ or the ‘Company’)
Further evidence of Colostrinin(TM) Activity in Reducing Cytotoxicity Related to Alzheimer’s Disease.
ReGen Therapeutics Plc (AIM:RGT) announces an advance e-publication cited on PubMed prior to full publication in the Journal of Alzheimer’s Disease confirming Colostrinin’s(TM) activity in Alzheimer’s Disease.
*Professor Michael Stewart, one of the co-authors said:
“Alzheimer’s disease is the most common form of dementia, affecting 18 million people worldwide. It is characterized by extracellular senile plaques consisting mainly of aggregated amyloid-beta (Aß) and intracellular neurofibrillary tangles, containing the cytoskeletal protein tau. A recent study by Froud et al. in Journal of Alzheimer’s disease has demonstrated that Colostrinin(TM) significantly relieves amyloid-beta (Aß)-induced cytotoxicity.”
The Abstract says:
Colostrinin(TM) (CLN) a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer’s disease patients. The molecular basis of the action of CLN has been studied in vitro using human neuroblastoma cell lines. The aim of the present study was to use quantitative immunocytochemistry and immunoblotting to investigate the ability of CLN to relieve amyloid-beta (Aß)-induced cytotoxicity in rat primary hippocampal neuronal cells. Our data confirm that CLN alleviates the effect of Aß-induced cytotoxicity and causes a significant reduction in the elevated levels of the antioxidant enzyme SOD1.
*Professor Michael G Stewart BSc. PhD, Department of Life Sciences of the Open University, Milton Keynes, MK7 6AA has been a consultant to ReGen Therapeutics Plc.
Note: The reference is DOI: 10.3233/JAD-2010-1382 and the digital object identifier can be used in a search engine to find the abstract.
For further information:
Percy Lomax
ReGen Therapeutics Plc
Tel No 020 7153 4920
Roland Cornish/Felicity Geidt
Beaumont Cornish Limited
Tel No 020 7628 3396
David Scott/Nick Bealer
Alexander David Securities Limited
Tel No 020 7448 9800