Issue of Shares

27/10/2008

As announced by ReGen Therapeutics Plc (“ReGen” or the “Company”), (AIM: RGT) on 26 March 2008, ReGen has entered into a £2,000,000 equity credit facility agreement with Duke Holdings Corporation Limited (“Duke”) to provide a drawdown of monies in exchange for ordinary shares in the Company (the “Facility”).

In accordance with the terms of the Facility and pursuant to a drawdown notice from the Company issued on 9 October 2008, Duke has now subscribed for 709,570 new ordinary shares of 0.01p each at 6.4p per share. This will provide the Company with £45,691, before expenses to provide working capital for the Company.

In addition, and pursuant to the agreements with Laurel Moody and Julian Beare whereby they had agreed to take their fees in ordinary shares, they have been issued respectively with 86,207 new ordinary shares and 37,500 new ordinary shares at a price of 10p per share.

The 833,277 new ordinary shares, which will represent 6 per cent of the enlarged issued share capital of the Company (13,901,798 ordinary shares), will rank pari passu in all respects with the existing ordinary shares in the Company.

Application has been made to the London Stock Exchange for the new ordinary shares to be admitted to trading on AIM and dealings in the new ordinary shares are expected to commence on 30 October 2008.

Percy Lomax, Chairman and Chief Executive commented:

‘ReGen is pleased to see that its prudence in taking out equity drawdown facilities has enabled it to access cash in these difficult markets. The Company continues to take all possible steps to conserve cash and is exploring all opportunities to develop its revenue streams as quickly as possible.

For further information, please contact:

Percy Lomax
ReGen Therapeutics Plc
Tel: 020 7153 4920

Roland Cornish/Felicity Geidt
Beaumont Cornish Limited
Tel No 020 7628 3396

David Scott/Nick Bealer
Alexander David Securities Limited
Tel: 020 7448 9820